This site is intended for U.S. healthcare professionals
This site is intended for U.S. healthcare professionals
Understand the connection between rapid weight loss and gallstone formation, and how to protect your patients.
Rapid weight loss is a known risk factor for gallstones
Medications like Ozempic® and Wegovy® can lead to rapid weight loss
Weight loss may be most pronounced early on, which could make patients more vulnerable to forming gallstones.6-8
Risk of gallbladder or biliary disease is more strongly associated with use of GLP-1 agonists for weight loss than for diabetes, with higher doses, and with longer treatment.5
With GLP-1 agonists, the rate of weight loss may be particularly rapid during the first 12 to 16 weeks of treatment.7,8 Prescribing information for many GLP-1 agonists includes warnings of the risk of gallbladder disease, including cholelithiasis and cholecystitis.9-15
Before putting a patient on GLP-1 therapy for the purpose of weight loss, consider gallstone prophylaxis before it is too late.
According to a study conducted with tirzepatide 10 & 15 mg (including a placebo group), the weight loss patients experienced was most rapid towards the beginning of therapy.
With GLP-1 agonists, the rate of weight loss may be particularly rapid during the first 12 to 16 weeks of treatment.
Prescribing information for many GLP-1 agonists includes warnings of the risk of gallbladder disease, including cholelithiasis and cholecystitis.
A major risk factor for gallstone development is rapid weight loss. Consider Reltone. Reltone (ursodiol capsules, USP) is proven therapy for preventing gallstone formation during rapid weight loss in patients with a BMI ≥ 30.
Reltone (ursodiol capsules, USP) is proven therapy for preventing
gallstone formation during rapid weight loss
Participants (BMI ≥38; N=1,004) received either ursodiol 600 mg/day or placebo. Duration: 16 weeks. Weight loss (avg): 47-50 lbs.
Participants (BMI ≥40; N=312) received either ursodiol 600 mg/day or placebo. Duration: 6 months. Weight loss (avg): 64-74 lbs.
No Hassle for Your Patients
All prescriptions of Reltone are available for as little as $0 for commercially insured patients.*
This website is intended solely for licensed healthcare professionals (HCPs), including physicians, nurse practitioners, physician assistants, pharmacists, and other qualified medical professionals in the United States.
The information contained on this site includes clinical data, prescribing information, and other content that is intended exclusively for healthcare professionals and is not appropriate for general consumers or patients. If you are a patient or caregiver, please visit https://reltone.com/patient/ or speak with your healthcare provider.
By clicking “I Confirm” below, you certify that you are a licensed healthcare professional and that you are accessing this information in your professional capacity.
This promotional content is intended for US healthcare professionals only. RELTONE® is a FDA-approved prescription medicine for people with certain types of gallstones. Please see full Prescribing Information / Brief Summary linked below.
This website is intended for U.S. healthcare professionals only.
The information provided on this site includes prescribing information, clinical data, and other scientific and promotional materials related to RELTONE® (ursodiol) and is intended for licensed healthcare professionals in the United States.
If you are a patient, please visit the patient section of the website or speak with your healthcare provider.
By clicking “I Confirm” below, you acknowledge that you are a U.S. healthcare professional accessing this website in your professional capacity.
Please see the Full Prescribing Information and Important Safety Information for RELTONE® linked below.
