A proven therapy for dissolving gallstones

Gallstone Dissolution Therapy for Patients Unable or Unwilling to Undergo Surgery

Efficacy of Reltone: Nonsurgical Dissolution

Reltone provides a clinically effective non-surgical alternative for dissolution of radiolucent, noncalcified gallbladder stones <20 mm.

Proven gallstone dissolution up to 50%; prevention up to 87% reduction post-bariatric surgery

81%

Complete dissolution in patients with stones ≤5 mm diameter¹

30%

Complete dissolution in patients with stones <20 mm treated for up to 2 years¹

The risk for preexisting gallstones increases to 10% after 5 years⁶

Nearly one third of gallstones can become symptomatic after 15 years¹⁷

(stones ≤5 mm diameter)¹

(stones <20 mm diameter; treatment ≤2 years)¹

Gallstones Prevalence May Be Underestimated in Clinical Practice

Who is at risk for developing gallstones?⁶

Gallstones develop in 10% to 15% of adults.

Obesity (BMI ≥30)

Age ≥40 years

Females

Elevated estrogen levels (e.g., pregnancy, oral contraceptives)

Ethnicity (Native American, Hispanic)

Diabetes and other metabolic conditions

Use of GLP-1 receptor agonists:

Risk of gallbladder or biliary disease is associated with use of GLP-1 agonists.⁵

With GLP-1 agonists, the rate of weight loss may be particularly rapid during the first 12 to 16 weeks of treatment.^7,8

Prescribing information for many GLP-1 agonists includes warnings of the risk of gallbladder disease, including cholelithiasis and cholecystitis.^9-15

Asymptomatic Gallstones Can Become Symptomatic

10% within 5 years, and nearly one-third become symptomatic after 15 years without treatment.¹⁷

There is Reason for Growing Concern Too

Risks Associated with Untreated Gallstones^6,18

Cholecystitis (inflammation of the gallbladder)

Biliary tract obstruction

Gallstone pancreatitis

Dissolution May Be Preferable to Surgery

Risks of Surgical Intervention (Cholecystectomy):

Over 700,000 procedures annually, though common, significant risks exist.¹⁹

Complication Rates:

Bile duct injury¹⁹

0.3% to 1.5%

Affecting approximately 2,500 patients each year

Mortality related to bile duct injury¹⁹

1.8% to 4.6%

Affecting approximately 2,500 patients each year

General surgical morbidity²⁰

1.6% to 5.3%

Overall complications

General surgical mortality²⁰

0.08% to 0.14%

Affecting approximately 2,500 patients each year

Surgery remains a standard treatment and Reltone is intended for patients with specific contraindications or preferences.